MMPs: A Surprising Ingredient in Healthy Wound Repair

How much do you really know about MMPs? MMPs are often portrayed as the adversary in wound repair and TIMPs are frequently considered the hero. The truth is more complex than this. The proper functioning of each depends on the other and they work together to help create a balanced environment that keeps tissue healthy. Click play for a 10-minute video on the compound roles of these proteins and the ways they work to facilitate tissue restoration.

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What is Hyaluronic Acid?

By now, most of us have probably heard of hyaluronic acid (HA). Whether as a pain reliever for joints and tendons or a main ingredient in anti-aging serum, hyaluronic acid is widely-recognized as a key molecule found throughout the body.  But what is it that makes HA so unique? How does it work natively and where can it be sourced from? Watch this short video as StimLabs’ scientist, Annelise Roy, gives the lowdown on hyaluronic acid and its versatile functions.

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Is an MSC a stem cell or a signaling cell?

Over the past few decades, stem cells have become synonymous with regenerative medicine. Stem cells are unspecialized cells that have the capacity for self-renewal and the ability to specialize into different adult cell types. With the dawn of stem cell therapies has come many misconceptions; the most prevalent misconception is that stem cell therapies involve embryonic stem cells. In fact, the majority of stem cell therapies are derived from adult stem cells that are harvested from the bone marrow or fat of adults. These treatments were initially based on the underlying principle that infused stem cells congregate at injured tissue sites, differentiate into the injured tissue type, and replace the injured tissue with new, healthy tissue. 

Mesenchymal stem cells (MSCs) are an adult stem cell type that feature heavily in cell therapies. They are a multipotent cell that can specialize into mesenchymal tissue types (e.g. bone, cartilage, fat). When MSCs were discovered, they were branded as ‘stem cells’ because they exhibited in vitro multipotency capabilities. This discovery made them an attractive therapy option for clinicians. Since then, hundreds of cell therapy studies have been performed with living MSCs infusions. This paradigm has fueled the way regenerative medicine has designed and developed stem cell therapies for over a decade.

But do MSCs work the way we originally thought? 

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The Benefits of Balance

We need everything in moderation. 

This isn’t just a saying used by doctors and nutritionists. It is a basic biological principle. Our bodies survive day-to-day by maintaining a dynamic balance of opposing forces and signals. Our “normal” is actually the successful balancing of a seesaw. A stable equilibrium.

The scientific term for this balancing act is homeostasis. This concept is not new. It was originally described by ancient Greek philosophers who thought that life consisted of elements in “dynamic opposition or alliance” to one another. Over two millennia later, we can still see the validity of homeostasis even at the molecular level when studying signaling pathways in the body.

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