What is Hyaluronic Acid?

By now, most of us have probably heard of hyaluronic acid (HA). Whether as a pain reliever for joints and tendons or a main ingredient in anti-aging serum, hyaluronic acid is widely-recognized as a key molecule found throughout the body.  But what is it that makes HA so unique? How does it work natively and where can it be sourced from? Watch this short video as StimLabs’ scientist, Annelise Roy, gives the lowdown on hyaluronic acid and its versatile functions.

MKTG 18-028 Rev 01

First Patient Enrolled in Revita® Spine Study

We’re excited to announce our first level 1 clinical study for Revita full thickness placental allograft!


This clinical trial will assess the safety and efficacy of Revita placement following lumbar microdiscectomy procedures. Common complications following microdiscectomy procedures include scar tissue formation and reherniation, which are known to cause back and leg pain. Patients with extensive scar tissue are 3.2 times more likely to experience recurrent radicular pain than those with less extensive scarring1.

The use of a barrier membrane, such as Revita, is expected to reduce the rate of occurrence for these types of complications and improve functional outcomes following surgery. The first patient has been enrolled in a 182-patient multi-center randomized controlled single-blinded (patient) trial evaluating the use of Revita as a barrier membrane to reduce these types of complications and improve functional outcomes. More information on this study can be found in the press release.

We are thrilled to have this trial underway, and we are continuing to invest in robust clinical validation of both Revita and Ascent through several case series and large randomized controlled trials.

MKTG 18-020 Rev 01

1. Ross et al,. Association between peridural scar and recurrent radicular pain after lumbar discectomy: magnetic resonance evaluation. ADCON-L European Study Group. AJNR Am J Neuroradiol, January 1998, 19:183–186

Is an MSC a stem cell or a signaling cell?

Over the past few decades, stem cells have become synonymous with regenerative medicine. Stem cells are unspecialized cells that have the capacity for self-renewal and the ability to specialize into different adult cell types. With the dawn of stem cell therapies has come many misconceptions; the most prevalent misconception is that stem cell therapies involve embryonic stem cells. In fact, the majority of stem cell therapies are derived from adult stem cells that are harvested from the bone marrow or fat of adults. These treatments were initially based on the underlying principle that infused stem cells congregate at injured tissue sites, differentiate into the injured tissue type, and replace the injured tissue with new, healthy tissue. 

Mesenchymal stem cells (MSCs) are an adult stem cell type that feature heavily in cell therapies. They are a multipotent cell that can specialize into mesenchymal tissue types (e.g. bone, cartilage, fat). When MSCs were discovered, they were branded as ‘stem cells’ because they exhibited in vitro multipotency capabilities. This discovery made them an attractive therapy option for clinicians. Since then, hundreds of cell therapy studies have been performed with living MSCs infusions. This paradigm has fueled the way regenerative medicine has designed and developed stem cell therapies for over a decade.

But do MSCs work the way we originally thought? 

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The Benefits of Balance

We need everything in moderation. 

This isn’t just a saying used by doctors and nutritionists. It is a basic biological principle. Our bodies survive day-to-day by maintaining a dynamic balance of opposing forces and signals. Our “normal” is actually the successful balancing of a seesaw. A stable equilibrium.

The scientific term for this balancing act is homeostasis. This concept is not new. It was originally described by ancient Greek philosophers who thought that life consisted of elements in “dynamic opposition or alliance” to one another. Over two millennia later, we can still see the validity of homeostasis even at the molecular level when studying signaling pathways in the body.

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Redefining Regenerative Medicine

The healing cascade is a complex and dynamic series of phases that has been studied in depth and characterized into three general phases: inflammation, proliferation, and maturation. During these stages, signaling proteins and local cells work to repair the injured tissue back to its original form. The problem? The healing process, like many functions of the body, is not perfect. Scars, for example, are a visual representation of how a wound is unable to fully return to its original form and function. Even when a scar appears to have dissipated, the ‘new’ tissue formed is dissimilar and more vulnerable than the original tissue.

What’s the point?

In an ideal world, tissue would be restored perfectly back to its inherent function and structure. This notion of optimized healing is the foundation for StimLabs' conception. StimLabs believes in optimizing the healing cascade by advancing research and development within regenerative medicine.

Back up. What is regenerative medicine?

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